Author

Bret Holguin

Ionis Pharmaceuticals (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

Alfred E. ChappelliD· 1 shared Andrew RodrigueziD· 1 shared António Pinto‐DuarteiD· 1 shared Eric E. SwayzeiD· 1 shared Frank RigoiD· 1 shared Fredrik KammeiD· 1 shared Guillaume JacquotiD· 1 shared Hans J. GausiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Alfred E. ChappellORCID

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1 paper

Recent·Most cited

Delivery of small interfering RNA and antisense oligonucleotides across the blood-brain barrier with monovalent transferrin receptor 1 binding VHH-Fc fusion proteins

Ian J. Huggins, Michele Carrer, Jinro A. Santos, Michael Fazio, Bret Holguin, Stevee Phi, Thazha P. Prakash, Megan E. Afetian, Mohsen Afshar Bakooshli, Stephanie K. Klein, Rodrigo Galindo‐Murillo, Andrew Rodriguez, Fredrik Kamme, Hans J. Gaus, Alfred E. Chappell, , Eric E. Swayze

This paper develops a VHH-Fc fusion protein to deliver siRNAs and ASOs across the BBB in rodents and NHPs, showing that binding affinity, DAR, and conjugation site affect delivery efficiency.

bioRxiv · Aug 20, 2026 · PreprintNeuroscience