Author

Fredrik Kamme

Ionis Pharmaceuticals (United States)ORCID 0000-0003-2877-6954Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:non-human primate· 1

Frequent Co-Authors

Christine Hong· 2 shared Adamantia F. FragopoulouiD· 1 shared Addison J. LanaiD· 1 shared Adriana‐Natalia MurgociiD· 1 shared Ahmed M. OsmaniD· 1 shared Alfred E. ChappelliD· 1 shared Anastasios E. DamdimopoulosiD· 1 shared Andrew RodrigueziD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

Christine Hong

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 20, 2026

Delivery of small interfering RNA and antisense oligonucleotides across the blood-brain barrier with monovalent transferrin receptor 1 binding VHH-Fc fusion proteins

Ian J. Huggins, Michele Carrer, Jinro A. Santos…·Eric E. Swayze

This paper develops a VHH-Fc fusion protein to deliver siRNAs and ASOs across the BBB in rodents and NHPs, showing that binding affinity, DAR, and conjugation site affect delivery efficiency.

DOI 10.64898/2026.08.13.744307

mousenon-human primate

𝕏 PostBluesky

ImmunologybioRxivPreprintFeb 22, 2025

Glioma-induced DNMT3A-dependent reduction of DNA methylation in microglia promotes a transient anti-tumoral phenotype.

Mathilde Cheray, Adriana‐Natalia Murgoci, Adamantia F. Fragopoulou…·Bertrand Joseph

This study shows that glioma-induced DNMT3A reduction in microglia leads to DNA demethylation and an anti-tumoral phenotype, suggesting DNMT3A as a therapeutic target for glioblastoma.

DOI 10.1101/2025.02.22.639606

mousebulk RNA-seq

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NeurosciencebioRxivPreprintNov 12, 2024

Mechanisms driving epigenetic and transcriptional responses of microglia in a neurodegenerative lysosomal storage disorder model

Christopher D. Balak, Johannes C. M. Schlachetzki, Addison J. Lana…·Christopher K. Glass

This study investigates how lysosomal dysfunction in microglia drives epigenetic and transcriptional changes in a mouse model of Sanfilippo syndrome, revealing shared mechanisms with Alzheimer's disease.

3 citations

mousescRNA-seq

𝕏 PostBluesky