Author

Brett N. Cain

University of Illinois Urbana-Champaign

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Paul J. HergenrotheriD· 2 shared Adrián González-LópeziD· 1 shared Andrei L. OstermaniD· 1 shared Daniel S. D. LarssoniD· 1 shared Gee W. LauiD· 1 shared James E. KentiD· 1 shared John D Williams· 1 shared M. SelmeriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

Paul J. HergenrotherORCID

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2 papers

Recent·Most cited

Fatty acid biosynthesis inhibitors fabimycin and triclosan trigger distinct resistance mutations in FabI and potently kill Gram-negative pathogens

Brett N. Cain, James E. Kent, Marinela L. Elane, John D Williams, Myung Rhul Lee, Gee W. Lau, Paul J. Hergenrother, Andrei L. Osterman

This study evaluates resistance profiles of E. coli to fabimycin and triclosan, showing distinct resistance mutations and minimal cross-resistance.

ACS Infectious Diseases · Aug 24, 2026Peer-reviewedMicrobiology

Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane

Adrián González-López, Daniel S. D. Larsson, Ravi Kiran Koripella, Brett N. Cain, Martin Garcia Chavez, Paul J. Hergenrother, Suparna Sanyal, M. Selmer

The paper presents cryo-EM structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and its derivative FA-cyclopentane, revealing binding interactions and structural details relevant to drug discovery.

Scientific Reports · Jun 20, 2024Peer-reviewedMolecular Biology