Author

Paul J. Hergenrother

University of Illinois Urbana-ChampaignORCID 0000-0001-9018-3581Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:E. coli· 1

Frequent Co-Authors

Brett N. Cain· 2 shared Adrián González-LópeziD· 1 shared Amber L. MosleyiD· 1 shared Andrei L. OstermaniD· 1 shared Aruna B. WijeratneiD· 1 shared Avery M. RunnebohmiD· 1 shared Brendan A.C. HarleyiD· 1 shared Daniel S. D. LarssoniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

Brett N. Cain

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cancer BiologyJournal of Proteome ResearchPeer-reviewedNov 6, 2026

Unraveling Systemic Responses to NQO1-Activated IB-DNQand Rucaparib Single and Dual Agent Therapy in Triple-Negative Breast Cancers

Avery M. Runnebohm, H. R. Sagara Wijeratne, Sarah A. Peck Justice…·Amber L. Mosley

This study evaluates the effects of IB-DNQ and Rucaparib on TNBC cells, revealing synergistic effects and novel protein biophysical changes via thermal proteome profiling.

DOI 10.1021/acs.jproteome.6c00632

humanproteomics

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MicrobiologyACS Infectious DiseasesPeer-reviewedAug 24, 2026

Fatty acid biosynthesis inhibitors fabimycin and triclosan trigger distinct resistance mutations in FabI and potently kill Gram-negative pathogens

Brett N. Cain, James E. Kent, Marinela L. Elane…·Andrei L. Osterman

This study evaluates resistance profiles of E. coli to fabimycin and triclosan, showing distinct resistance mutations and minimal cross-resistance.

DOI 10.1021/acsinfecdis.6c00339

E. coliwhole-genome sequencing

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BioengineeringbioRxivPreprintJul 8, 2025

Multicellular model of temozolomide resistance in glioblastoma reveals phenotypic shifts in drug response and migratory potential

Victoria A. Kriuchkovskaia, Ela K. Eames, Sydney A. McKee…·Brendan A.C. Harley

This study uses a 3D hydrogel model to investigate TMZ resistance in GBM by examining drug response and migration in heterogeneous cell populations.

3 citations

humanbulk RNA-seq

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Molecular BiologyScientific ReportsPeer-reviewedJun 20, 2024

Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane

Adrián González-López, Daniel S. D. Larsson, Ravi Kiran Koripella…·M. Selmer

The paper presents cryo-EM structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and its derivative FA-cyclopentane, revealing binding interactions and structural details relevant to drug discovery.

17 citations

bacteria (other)experimental assay

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