Suparna Sanyal

Molecular mechanism of IF1- and IF2-driven translation initiation in bacteria

This study elucidates the molecular mechanism of IF1 and IF2 in bacterial translation initiation using cryo-EM and fast-kinetics, showing their roles in subunit association, GTP hydrolysis, and Pi release.

Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis

The paper elucidates how FusB rescues protein synthesis from fusidic acid inhibition by altering EF-G conformation and facilitating its dissociation from the ribosome.

Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation

This study identifies that Δ133p53α and Δ160p53α isoforms exert a dominant-negative effect on p53 by co-aggregating with full-length p53, disrupting its function.

Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane

The paper presents cryo-EM structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and its derivative FA-cyclopentane, revealing binding interactions and structural details relevant to drug discovery.

Experimental evolution of Escherichia coli harboring an ancient translation protein

The paper engineers an ancient tufB gene into E. coli and evolves it to study adaptive responses to the ancient protein.