Loss of Ferroptosis-suppressors Accelerates Breast Cancer Recurrence by Promoting Dormancy Exit
Emily K. Shea, Matthew Lawrence-Paul, Amulya Sreekumar, Brian Benz, Christopher Sterner, Jianping Wang, Yan Chen, Tien-Chi Pan, George Belka, Lewis A. Chodosh
This study identifies PNPLA2, GOT1, and GPX4 as ferroptosis-suppressors whose loss accelerates breast cancer recurrence by promoting dormancy exit and enhancing ferroptosis resistance in dormant cells.
bioRxiv · Oct 28, 2026 · PreprintCancer Biology