Emily K. Shea

Loss of Ferroptosis-suppressors Accelerates Breast Cancer Recurrence by Promoting Dormancy Exit

This study identifies PNPLA2, GOT1, and GPX4 as ferroptosis-suppressors whose loss accelerates breast cancer recurrence by promoting dormancy exit and enhancing ferroptosis resistance in dormant cells.

A genetically defined injured C-fibre nociceptor associated with neuromasdrives chronic spontaneous neuropathic pain

The paper identifies a specific subtype of injured C-fibre nociceptors in neuromas that drive chronic spontaneous neuropathic pain in mice.

Massively parallel phenotyping of variant impact in cancer with Perturb-seq reveals a shift in the spectrum of cell states induced by somatic mutations

The paper uses Perturb-seq to assess the phenotypic impact of somatic variants in cancer, revealing a continuum of gain-of-function KRAS variants.