Author

Tien-Chi Pan

University of PennsylvaniaORCID 0000-0002-5380-0867Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Organism:mouse· 1

Frequent Co-Authors

Amulya SreekumariD· 2 shared Lewis A. ChodoshiD· 2 shared Anupma NayakiD· 1 shared Brian Benz· 1 shared Charles‐Antoine AssenmacheriD· 1 shared Christopher J. SterneriD· 1 shared Christopher Sterner· 1 shared David A. MankoffiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Amulya SreekumarORCID

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2 papers

Recent·Most cited

Loss of Ferroptosis-suppressors Accelerates Breast Cancer Recurrence by Promoting Dormancy Exit

Emily K. Shea, Matthew Lawrence-Paul, Amulya Sreekumar, Brian Benz, Christopher Sterner, Jianping Wang, Yan Chen, Tien-Chi Pan, George Belka, Lewis A. Chodosh

This study identifies PNPLA2, GOT1, and GPX4 as ferroptosis-suppressors whose loss accelerates breast cancer recurrence by promoting dormancy exit and enhancing ferroptosis resistance in dormant cells.

bioRxiv · Oct 28, 2026 · PreprintCancer Biology

Residual Breast Cancer Cells Co-opt SOX5-driven Endochondral Ossification to Maintain Dormancy

Amulya Sreekumar, Eric R. Blankemeyer, Christopher J. Sterner, Tien-Chi Pan, Dhruv K. Pant, Sarah Acolatse, Hamza Turkistani, George K. Belka, Anupma Nayak, Sean Carlin, Charles‐Antoine Assenmacher, Mark A. Sellmyer, David A. Mankoff, Lewis A. Chodosh

This study identifies SOX5 as a key factor enabling residual breast cancer cells to maintain dormancy through endochondral ossification, improving recurrence-free survival.

Cancer Discovery · Dec 10, 2025Peer-reviewedCancer Biology