John A. Wolf

PIGMENT: A deep learning framework for Porcine Immunohistochemistry seGMENTation

PIGMENT is a deep learning framework that automates the segmentation and quantification of APP-positive pathology in porcine white matter histology, achieving high detection rates with limited expert annotations.

Disrupted Hippocampal Theta-Gamma Coupling and Spike-Field Coherence Following Experimental Traumatic Brain Injury

This study investigates changes in hippocampal oscillations after TBI, finding disrupted theta-gamma coupling and altered spike-field coherence in injured rats.

Increased CD3 Immunoreactive Cells Persist Chronically in the Brain Parenchyma in Association with Focal Cortical Contusion following Experimental TBI

This study shows that T-cell infiltration persists chronically in the brain after focal cortical contusion in swine, but not with inertial injury, suggesting an adaptive immune response to TBI.

Hippocampal Interneuronal Dysfunction and Hyperexcitability in a Porcine Model of Concussion

This study examines electrophysiological changes in hippocampal neurons and their subtypes in a porcine model of concussion, finding altered properties in interneurons and hyperexcitability in pyramidal neurons.

A Porcine Model of Peripheral Nerve Injury Enabling Ultra-Long Regenerative Distances: Surgical Approach, Recovery Kinetics, and Clinical Relevance

This paper describes a porcine model for studying long-distance peripheral nerve regeneration, focusing on surgical techniques and outcomes for ultra-long regenerative distances.

Single Cell Spatial Chromatin Analysis of Fixed Immunocytochemically Identified Neuronal Cells

CHEX-seq identifies open-chromatin regions in fixed single cells, enabling spatial chromatin analysis in complex environments.

Multichannel Silicon Probes for Awake Hippocampal Recordings in Large Animals

This study evaluates multichannel silicon probes for chronic electrophysiological recordings in large animals, finding that probe cross-sectional area and design affect single-unit performance and long-term viability.

Electrophysiological Signature Reveals Laminar Structure of the Porcine Hippocampus

The paper characterizes the laminar structure of the porcine hippocampus using histology and electrophysiology, finding features similar to both rodents and primates.