Gain-of-function mutant p53 regulates long-noncoding RNA LINC00643 to modulate HIF1α in glioblastoma
Ying Zhang, Fang Yuan, Myron Keith Gibert, Collin Dube, Kadie Hudson, Cassandra Grello, Brian J. Reon, Shekhar Saha, Yunan Sun, Pawel Marcinkiewicz, Anindya Dutta, David Chief, Eric C. Holland, Roger Abounader
This study identifies LINC00643 as a target of GOF-MUT-p53 in glioblastoma, showing it suppresses tumor growth by repressing HIF1α under hypoxia.
bioRxiv · Sep 16, 2025 · PreprintCancer Biology