Collin Dube

Microenvironment T-Type calcium channels regulate neuronal and glial processes to promote glioblastoma growth

This study shows that microenvironment T-type calcium channels promote glioblastoma growth by regulating neuronal and glial processes, and that blocking these channels with mibefradil enhances the effectiveness of standard therapies.

Gain-of-function mutant p53 regulates long-noncoding RNA LINC00643 to modulate HIF1α in glioblastoma

This study identifies LINC00643 as a target of GOF-MUT-p53 in glioblastoma, showing it suppresses tumor growth by repressing HIF1α under hypoxia.

Discovery and therapeutic exploitation of Master Regulatory miRNAs in Glioblastoma

The paper identifies master regulatory miRNAs in glioblastoma and develops a therapeutic delivery method to inhibit tumor growth.

FHL5 controls vascular disease-associated gene programs in smooth muscle cells

This study identifies FHL5 as a causal gene for vascular disease risk through eQTL colocalization and functional analyses, showing its role in vascular remodeling and calcification.