Shekhar Saha

tRF-3021a Supports Invasiveness, Apoptosis Resistance, and Global Protein Synthesis in Cancer Cell Lines

The paper identifies tRF-3021a as a cancer-promoting tRNA-derived fragment that supports invasiveness, apoptosis resistance, and global protein synthesis in cancer cell lines.

Microenvironment T-Type calcium channels regulate neuronal and glial processes to promote glioblastoma growth

This study shows that microenvironment T-type calcium channels promote glioblastoma growth by regulating neuronal and glial processes, and that blocking these channels with mibefradil enhances the effectiveness of standard therapies.

Gain-of-function mutant p53 regulates long-noncoding RNA LINC00643 to modulate HIF1α in glioblastoma

This study identifies LINC00643 as a target of GOF-MUT-p53 in glioblastoma, showing it suppresses tumor growth by repressing HIF1α under hypoxia.

Discovery and therapeutic exploitation of Master Regulatory miRNAs in Glioblastoma

The paper identifies master regulatory miRNAs in glioblastoma and develops a therapeutic delivery method to inhibit tumor growth.

Fob1-dependent condensin recruitment and loop extrusion on yeast chromosome III

The paper identifies Fob1-dependent condensin recruitment and loop extrusion at the RDT1 locus on yeast chromosome III, linking it to MATa-specific organization during mating-type switching.

tRForest: a novel random forest-based algorithm for tRNA-derived fragment target prediction

tRForest improves tRNA fragment target prediction using random forest, validated in cell lines and showing enrichment in neuronal function.

Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors

The paper identifies distinct structural domains in the MUNC lncRNA that regulate different promyogenic genes through cis and trans mechanisms.

ATAC-seq identifies thousands of extrachromosomal circular DNA in cancers and cell lines

The paper shows that ATAC-seq can detect thousands of extrachromosomal circular DNAs in cancer and cell lines without specific enrichment.

The Pan-Cancer Landscape of Prognostic Germline Variants in 10,582 Patients

The paper identifies prognostic germline variants in 10,582 cancer patients using multivariate Cox regression, showing their association with patient outcomes beyond clinical data.