Rewiring the fusion oncoprotein EWS/FLI1 in Ewing sarcoma with bivalent small molecules
Michael J. Bond, Ryan P. Golden, Giulia DiGiovanni, Briana Howard, Roman C. Sarott, Basel A. Karim, Sai P. Gourisankar, Gabriela Alexe, Kenneth N. Ross, Nathanael S. Gray, Kimberly Stegmaier
This study develops a bivalent small molecule, EB-TCIP, that relocalizes EWS/FLI1 to induce BCL6 target genes, demonstrating a strategy to target fusion oncoproteins in Ewing sarcoma.
bioRxiv · Mar 14, 2025 · PreprintCancer Biology