Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice
Atsuki En, Hanumakumar Bogireddi, Briana Thomas, Alexis V. Stutzman, Sachie Ikegami, Brigitte LaForest, Omar Almakki, Peter Pytel, Ivan P. G. Moskowitz, Kohta Ikegami
The paper shows that NE ruptures occur before ECM signaling and disease in Lamin-cardiomyopathy mice without activating cGAS-STING.
Cell Reports · May 29, 2024Peer-reviewedMolecular Biology