RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site.
Katarzyna Z. Haza, Heather L. Martin, Ajinkya Rao, Amy L. Turner, Sophie E. Saunders, Britta Petersen, Christian Tiede, Kevin W. Tipping, Anna Ah-San Tang, Modupe O. Ajayi, Thomas J. Taylor, Maia Harvey, Keri M. Fishwick, Thomas L. Adams, Thembaninkosi G. Gaule, , Darren Charles Tomlinson
This paper identifies two RAS-binding Affimer proteins that inhibit RAS function and reveal a novel druggable SII/3 pocket.
Nature Communications · Jun 30, 2021Peer-reviewedMolecular Biology