Alexander L. Breeze

This paper expresses and functionally characterizes the oncogenic RTK FGFR3-TACC3 using cell-free protein expression, achieving significant kinase activity.

The paper identifies three SNPs in EFCAB4B (CRACR2A) associated with increased risk of COVID-19 fatality through missense mutations affecting protein structure and function.

This paper identifies two RAS-binding Affimer proteins that inhibit RAS function and reveal a novel druggable SII/3 pocket.