Variant mutation in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation
Hannah C. Kubinski, Hannah W. Despres, Bryan A. Johnson, Madaline M. Schmidt, Sara A. Jaffrani, Margaret G. Mills, Kumari Lokugamage, Caroline M. Dumas, David J. Shirley, Leah K. Estes, Andrew Pekosz, Jessica W. Crothers, Pavitra Roychoudhury, Alexander L. Greninger, Keith R. Jerome, , Emily A. Bruce
The paper identifies a mutation in the SARS-CoV-2 nucleocapsid protein that enhances viral infection by promoting dimer formation and altering virion structure.
bioRxiv · Mar 8, 2024 · PreprintMicrobiology