The decameric repeat (DR) of PSGL-1 functions as a basic antiviral unit in restricting HIV-1 infectivity
Han Yang, Leanna Sealey, Yajing Fu, Bryan M. Delfing, Christopher Lockhart, Linda D. Chilin, Sameer Tiwari, Mohsin Saleet Jafri, Dmitri K. Klimov, Yuntao Wu
This study identifies the decameric repeat (DR) of PSGL-1 as an essential antiviral unit that restricts HIV-1 infectivity by hindering virion attachment to target cells.
bioRxiv · May 14, 2025 · PreprintImmunology