A non-catalytic role for RFC in PCNA-mediated processive DNA synthesis
Gabriella N. L. Chua, Emily C. Beckwitt, Victoria Miller-Browne, Olga Yurieva, Dan Zhang, Bryce J. Katch, Nina Y. Yao, John W. Watters, Kaitlin Abrantes, Ryogo Funabiki, Xiaolan Zhao, Mike E. O’Donnell, Shixin Liu
This study reveals a non-catalytic role for RFC in stabilizing PCNA-Polδ interactions during DNA synthesis, essential for processive replication.
Cell · Jan 28, 2026Peer-reviewedBiophysics