BiophysicsCell ReportsPeer-reviewed
Dpb11 facilitates the colocalization of Mec1-Ddc2 with its activators on gapped DNA
Emily C. Beckwitt, Gabriella N. L. Chua, Shixin Liu, Mike E. O’Donnell
This study shows Dpb11 binds ssDNA and recruits Mec1-Ddc2 to ss-dsDNA junctions, facilitating checkpoint activation by bridging DNA gaps.
DOI 10.1016/j.celrep.2026.117660