Shixin Liu

This study shows Dpb11 binds ssDNA and recruits Mec1-Ddc2 to ss-dsDNA junctions, facilitating checkpoint activation by bridging DNA gaps.

This study uses cryo-EM to visualize E. coli RNAP collisions with roadblocks and other RNAPs, revealing structural changes and mechanisms of collision resolution.

This study reveals a non-catalytic role for RFC in stabilizing PCNA-Polδ interactions during DNA synthesis, essential for processive replication.

The paper identifies H3 serine 28 phosphorylation as a mechanism driving chromatin derepression and immune cell fate transitions by disrupting repressive chromatin domains.

This study develops a single-molecule platform to analyze mammalian transcription elongation dynamics and identifies kinetic regulation by elongation factors.