PCSK9 and High-Fat Diet Synergistically Induce Neurovascular Dysfunction and Neuroinflammation
Mengqi Zhang, Anudari Letian, Gregory A. Mohl, Brynn Kroke, Kajsa Arkelius, Claire Dudley Clelland, Emily L. Goldberg, Neel S. Singhal
This study shows that PCSK9 overexpression with high-fat diet in mice causes neurovascular dysfunction and cognitive deficits, including lipid-droplet accumulating microglia and vascular amyloid-beta deposition.
bioRxiv · Oct 29, 2025 · PreprintNeuroscience