Emily L. Goldberg

PCSK9 and High-Fat Diet Synergistically Induce Neurovascular Dysfunction and Neuroinflammation

This study shows that PCSK9 overexpression with high-fat diet in mice causes neurovascular dysfunction and cognitive deficits, including lipid-droplet accumulating microglia and vascular amyloid-beta deposition.

Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation

This study identifies nerve-associated macrophages (NAMs) as regulators of adipose homeostasis and inflammation during aging, showing their depletion accelerates inflammaging and impairs lipolysis.

Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth

This study shows that neutrophil TLR2 signaling promotes lipid uptake and storage, contributing to atherosclerotic plaque growth.

Reversible histone deacetylase activity catalyzes lysine acylation

The paper shows class I HDACs can catalyze beta-hydroxybutyrylation of lysine, a reversible modification, expanding the role of HDACs beyond traditional deacetylation.

Class I histone deacetylases catalyze lysine lactylation

This paper identifies class I HDACs as enzymes that catalyze lysine lactylation, showing that this modification is primarily formed through enzymatic action rather than non-enzymatic pathways.

A secondary β-hydroxybutyrate metabolic pathway linked to energy balance

This study identifies a secondary BHB metabolic pathway mediated by CNDP2, leading to BHB-amino acid metabolites that regulate energy balance in mice and humans.