PCSK9 and High-Fat Diet Synergistically Induce Neurovascular Dysfunction and Neuroinflammation
Mengqi Zhang, Anudari Letian, Gregory A. Mohl…·Neel S. Singhal
This study shows that PCSK9 overexpression with high-fat diet in mice causes neurovascular dysfunction and cognitive deficits, including lipid-droplet accumulating microglia and vascular amyloid-beta deposition.