Kajsa Arkelius

This study shows that ischemic stroke causes changes in claudin-5 isoform expression in rats, which correlate with worse neurological outcomes and BBB dysfunction.

This study shows that PCSK9 overexpression with high-fat diet in mice causes neurovascular dysfunction and cognitive deficits, including lipid-droplet accumulating microglia and vascular amyloid-beta deposition.

This study evaluates hexokinase-2 inhibitors' effects on post-stroke inflammation and neuroprotection, finding that selective inhibitors reduce microglial activation and improve functional outcomes.

This study investigates the role of PATJ in cell stress responses and vascular remodeling after stroke using a mouse model and CRISPR-Cas9 knockout cells.

This study shows that inhibiting LOX-1 and MMP-9 with drugs improves outcomes after delayed rt-PA treatment in stroke by reducing hemorrhage and edema.