Neel S. Singhal

This study identifies lipid metabolic reprogramming as a conserved mechanism conferring hypoxic and aging resilience in Arctic ground squirrels and C. elegans.

This study shows that PCSK9 overexpression with high-fat diet in mice causes neurovascular dysfunction and cognitive deficits, including lipid-droplet accumulating microglia and vascular amyloid-beta deposition.

This study evaluates hexokinase-2 inhibitors' effects on post-stroke inflammation and neuroprotection, finding that selective inhibitors reduce microglial activation and improve functional outcomes.

This study investigates the role of PATJ in cell stress responses and vascular remodeling after stroke using a mouse model and CRISPR-Cas9 knockout cells.

This study shows that targeting the VHL-HIF axis suppresses mortality and cellular damage caused by APOE4 and other stressors in C. elegans and mice.