Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau
Alessia Santambrogio, Sofia Lövestam, Michael A. Metrick, Thomas Löhr, Pu Xu, Nicholas C. T. Gallagher, Bernardino Francesco Ghetti, Byron Caughey, Sjors H. W. Scheres, Michele Vendruscolo
This study investigates tau filament assembly using mutant recombinant tau and brain homogenates, finding that specific mutations produce filaments resembling AD pathology.
FEBS Letters · Sep 30, 2025Peer-reviewedNeuroscience