Author

Pu Xu

University of CambridgeORCID 0000-0002-3785-7812Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:protein structure· 2 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Alessia SantambrogioiD· 2 shared Michele VendruscoloiD· 2 shared Bernardino Francesco GhettiiD· 1 shared Byron Caughey· 1 shared Daoyuan QianiD· 1 shared Michael A. MetrickiD· 1 shared Nicholas C. T. Gallagher· 1 shared Sjors H. W. ScheresiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiophysics

Alessia SantambrogioORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintJul 1, 2026

Complex coacervation reshapes the aggregation landscape of tau

Zexiang Han, Pu Xu, Yangteng Ou…·Tuomas P. J. Knowles

This study shows that complex coacervation changes tau aggregation by redirecting it to a distinct kinetic regime and altering amyloid properties.

DOI 10.64898/2026.06.27.734011

protein structureexperimental assay

NeuroscienceFEBS LettersPeer-reviewedSep 30, 2025

Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau

Alessia Santambrogio, Sofia Lövestam, Michael A. Metrick…·Michele Vendruscolo

This study investigates tau filament assembly using mutant recombinant tau and brain homogenates, finding that specific mutations produce filaments resembling AD pathology.

4 citations

humanprotein structure