Alessia Santambrogio

Complex coacervation reshapes the aggregation landscape of tau

This study shows that complex coacervation changes tau aggregation by redirecting it to a distinct kinetic regime and altering amyloid properties.

Tracking tau and cellular responses in human iPSC-microglia from uptake to seedable secretion in extracellular vesicles

This study shows human iPSC-derived microglia uptake and process tau fibrils, leading to secretion in extracellular vesicles that can seed tau aggregation in neurons.

Distinct mechanistic pathways of early tauopathy revealed by MAPT mutations

This study uses mouse models with tau mutations to show two distinct pathogenic mechanisms in tauopathies, with different progression patterns and responses to amyloid.

Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau

This study investigates tau filament assembly using mutant recombinant tau and brain homogenates, finding that specific mutations produce filaments resembling AD pathology.