Author

Eszter Katona

UK Dementia Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Adrian M. IsaacsiD· 3 shared Mireia CarcoléiD· 3 shared Alla MikheenkoiD· 2 shared Anny DevoyiD· 2 shared Benjamin DaviesiD· 2 shared Carmelo MiliotoiD· 2 shared Daniel Biggs· 2 shared Dario R. AlessiiD· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Adrian M. IsaacsORCID

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3 papers

Recent·Most cited

C9orf72 polyGA knock-in mice exhibit mild motor and proteomic changes consistent with ALS/FTD

Carmelo Milioto, Mireia Carcolé, Matteo Zanovello, Mhoriam Ahmed, Raja Sekhar Nirujogi, Daniel Biggs, Eszter Katona, Idoia Glaria, Almudena Santos, Anny Devoy, Pietro Fratta, Dario R. Alessi, Benjamin Davies, Linda Greensmith, Elizabeth Fisher, Adrian M. Isaacs

This study creates (GA)400 knock-in mice to model C9orf72 polyGA expression, finding mild motor dysfunction and proteomic changes in the spinal cord.

bioRxiv · May 30, 2025 · PreprintNeuroscience

Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo

Liam Kempthorne, Deniz Vaizoglu, Alexander J. Cammack, Mireia Carcolé, Martha J. Roberts, Alla Mikheenko, Alessia Fisher, Pacharaporn Suklai, Bhavana Muralidharan, François Kroll, Thomas G. Moens, Lidia Yshii, Stijn Verschoren, Benedikt V. Hölbling, Francisco C. Moreira, , Adrian M. Isaacs

This study demonstrates that CRISPR-CasRx reduces C9orf72 repeat RNAs and DPRs in vitro and in vivo, suggesting its therapeutic potential for ALS/FTD.

Nature Communications · Jan 8, 2025Peer-reviewedNeuroscience

PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons

Carmelo Milioto, Mireia Carcolé, Ashling Giblin, Rachel Coneys, Olivia N. Attrebi, Mhoriam Ahmed, Sam Harris, Byung Il Lee, Mengke Yang, Raja Sekhar Nirujogi, Daniel Biggs, Sally E. Salomonsson, Matteo Zanovello, Paula De Oliveira, Eszter Katona, , Adrian M. Isaacs

The paper generates C9orf72 DPR knock-in mice and identifies an extracellular matrix signature in C9ALS/FTD that is conserved across species and protected by TGF-β1 and COL6A1.

bioRxiv · Jul 17, 2023 · PreprintNeuroscience