Hypothalamic GABRA5-positive Neurons Control Obesity via Astrocytic GABA
Moonsun Sa, Eun-Seon Yoo, Wuhyun Koh, Mingu Gordon Park, Hyun‐Jun Jang, Yong Ryoul Yang, Mridula Bhalla, Jae‐Hun Lee, Jiwoon Lim, Woojin Won, Jea Kwon, Joon-Ho Kwon, Yejin Seong, Byungeun Kim, Heeyoung An, , Changjoon Justin Lee
This study identifies GABRA5-positive neurons in the lateral hypothalamic area that regulate obesity through astrocytic GABA release, showing that inhibiting astrocytic GABA reduces weight gain.
Nature Metabolism · Aug 31, 2023Peer-reviewedNeuroscience