Wuhyun Koh

This study shows that astrocytic volume transients mediated by TREK-1 and TRPA1 channels are essential for synaptic plasticity and spatial memory.

This study identifies GABRA5-positive neurons in the lateral hypothalamic area that regulate obesity through astrocytic GABA release, showing that inhibiting astrocytic GABA reduces weight gain.

This study investigates the role of PAT/SAT1 in MAO-B-dependent GABA synthesis in astrocytes, showing that PAT/SAT1 gene silencing reduces GABA synthesis and tonic inhibition.

This study identifies TMEM87A as a novel Golgi-resident cation channel, GolpHCat, which regulates pH homeostasis and is essential for brain function and memory.

This study shows that astrocytic urea cycle detoxifies Aβ-derived ammonia but impairs memory in Alzheimer's disease, suggesting ODC1 inhibition as a potential therapeutic strategy.

This study shows astrocytes regulate NMDAR tone through Best1-mediated glutamate and D-serine release, which is essential for cognitive flexibility and memory repotentiation during reversal learning.

This study shows that both vesicular and non-vesicular gliotransmission from astrocytes are necessary for synaptic plasticity and working memory, with impaired release causing memory deficits.