Mingu Gordon Park

This study identifies the astrocytic MAOB-GABA axis as a brake on spinal cord injury repair and shows that the inhibitor KDS2010 promotes recovery in animal models and has a safe profile in humans.

This study identifies GABRA5-positive neurons in the lateral hypothalamic area that regulate obesity through astrocytic GABA release, showing that inhibiting astrocytic GABA reduces weight gain.

This study investigates the role of PAT/SAT1 in MAO-B-dependent GABA synthesis in astrocytes, showing that PAT/SAT1 gene silencing reduces GABA synthesis and tonic inhibition.

This study shows astrocytes regulate NMDAR tone through Best1-mediated glutamate and D-serine release, which is essential for cognitive flexibility and memory repotentiation during reversal learning.