Jong‐Woo Sohn

A Normative Framework Dissociates Need and Motivation in Hypothalamic Neurons

The paper develops a normative framework to distinguish need and motivation in hypothalamic neurons using computational models and experimental paradigms, showing AgRP and LHLepR neurons encode need and motivation respectively.

Adaptive thermogenesis is mediated by GDF15 via the GFRAL neuronal axis in mice

This study identifies the GFRAL neuronal axis as critical for GDF15-mediated adaptive thermogenesis in white adipose tissue under mitochondrial stress.

Hypothalamic GABRA5-positive Neurons Control Obesity via Astrocytic GABA

This study identifies GABRA5-positive neurons in the lateral hypothalamic area that regulate obesity through astrocytic GABA release, showing that inhibiting astrocytic GABA reduces weight gain.

CDC50A dependent phosphatidylserine exposure induces inhibitory post-synapse elimination by microglia

The paper shows that CDC50A-dependent phosphatidylserine exposure acts as an 'eat-me' signal for microglia to eliminate inhibitory post-synapses.

Sensory Detection of Aversive and Appetitive Stimuli by CRF neurons

The paper shows that PVN CRF neurons respond rapidly to aversive and appetitive stimuli in mice, suggesting their role in sensory detection and neuroendocrine regulation.