Imaging Synaptic Vesicle Protein SV2C with 18F-UCB-F: An In Vitro Autoradiography and In Vivo NHP PET Study
Sangram Nag, V. C. Sousa, Rongfeng Zou, Anton Forsberg Morén, P. Datta, Y. Khani, Anne Valade, C. Vermeiren, P. Motte, J Mercier, Hans Ågren, C Halldin, Andrea Varrone
This study evaluates [18F]UCB-F as a PET radioligand for imaging SV2C, finding it unsuitable due to poor in vivo stability and brain retention.
ACS Chemical Neuroscience · Jun 26, 2026Peer-reviewedNeuroscience