Author

J Mercier

UCB Pharma (Belgium)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:mechanistic / dynamical model· 1 Organism:non-human primate· 1 Research Focus:protein folding & dynamics· 1 Organism:rat· 1

Frequent Co-Authors

Andrea VarroneiD· 2 shared Anne Valade· 2 shared Anton Forsberg Morén· 2 shared C. Vermeiren· 2 shared Hans ÅgreniD· 2 shared P. Motte· 2 shared Rongfeng ZouiD· 2 shared Sangram NagiD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersNeuroscience

Andrea VarroneORCID

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Author profile →

2 papers

Recent·Most cited

Imaging Synaptic Vesicle Protein SV2C with 18F-UCB-F: An In Vitro Autoradiography and In Vivo NHP PET Study

Sangram Nag, V. C. Sousa, Rongfeng Zou, Anton Forsberg Morén, P. Datta, Y. Khani, Anne Valade, C. Vermeiren, P. Motte, J Mercier, Hans Ågren, C Halldin, Andrea Varrone

This study evaluates [18F]UCB-F as a PET radioligand for imaging SV2C, finding it unsuitable due to poor in vivo stability and brain retention.

ACS Chemical Neuroscience · Jun 26, 2026Peer-reviewedNeuroscience

In silico evaluation of the effects of temperature on the affinity of the SV2C ligand UCB-1A to SV2 isoforms

Rongfeng Zou, Sangram Nag, Vasco C. Sousa, Anton Forsberg Morén, Miklós Tóth, Yasir Khani Meynaq, Elena Pedergnana, Anne Valade, C. Vermeiren, P. Motte, J Mercier, Xiaoqun Zhang, Per Svenningsson, Christer Halldin, Andrea Varrone, Hans Ågren

This study evaluates how temperature affects UCB-1A binding to SV2A and SV2C using experimental assays and molecular dynamics simulations, finding that binding to SV2C remains stable while SV2A shows temperature sensitivity.

bioRxiv · Mar 21, 2026 · PreprintBiochemistry