Andrea Varrone

This study evaluates [18F]UCB-F as a PET radioligand for imaging SV2C, finding it unsuitable due to poor in vivo stability and brain retention.

This study evaluates how temperature affects UCB-1A binding to SV2A and SV2C using experimental assays and molecular dynamics simulations, finding that binding to SV2C remains stable while SV2A shows temperature sensitivity.

This paper develops UCB-1A, the first PET radioligand for imaging SV2C, showing it binds selectively to SV2C in brain regions and is suitable for Parkinson's disease studies.

This study identifies a GGC expansion in the ZFHX3 gene as the cause of SCA4, associated with dysautonomia and motor neuron signs.

This study evaluates the accuracy and reliability of specific binding estimates for [11C]PBR28 using the SIME method, showing good precision and reliability for VS but variability in BPND.