Local mechanical heterogeneity drives epidermal cell delamination
Andreas Schoenit, Jérémy O’Byrne, Cécile Daubech, W. F. Schmidt, Lucas Anger, Yuan Shen, Matthias Rübsam, Risai Dubrall, Fanny Wodrascka, Raphaël Voituriez, Benoît Ladoux, Carien M. Niessen, René‐Marc Mège
This study identifies local mechanical heterogeneity as the driver of epidermal cell delamination through force balance changes and actomyosin remodeling in keratinocytes.
bioRxiv · Sep 1, 2026 · PreprintBiophysics