Carien M. Niessen

Desmoglein-1 coordinates cell proliferation and actin dynamics to promote epidermal morphogenesis.

This study uses scRNA-seq to show Dsg1 coordinates cell proliferation and actin dynamics to drive epidermal morphogenesis through a Dsg1-Nck1-N-WASP axis.

Local mechanical heterogeneity drives epidermal cell delamination

This study identifies local mechanical heterogeneity as the driver of epidermal cell delamination through force balance changes and actomyosin remodeling in keratinocytes.

Tissue-scale mechanics controls differentiation strategy and dynamics of epithelial multilayering

The paper shows that tissue mechanics control epithelial multilayering by regulating cell differentiation and movement strategies in the developing mouse epidermis.

Spectrin coordinates cell shape and signaling essential for epidermal differentiation

This study identifies spectrin as a key organizer of the keratinocyte actomyosin cortex that coordinates cell shape and signaling during epidermal differentiation.

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells

The paper shows that mechano-osmotic changes in pluripotent stem cells influence chromatin state and fate transitions by integrating mechanical and biochemical signals.

Piezo1 balances membrane tension and cortical contractility to stabilize intercellular junctions and maintain epithelial barrier integrity

Novel, postnatal manifestation of an epidermal barrier defect in a mouse model of isolated sulfite oxidase deficiency

This study identifies a postnatal skin barrier defect in Suox-/- mice, linking sulfite oxidase deficiency to epidermal dysfunction and early mortality.

Sphingolipid metabolism orchestrates the establishment of the adult hair follicle stem cell niche to control skin homeostasis

This study identifies CerS4's role in regulating hair follicle stem cell niche formation through sphingolipid metabolism, impacting skin homeostasis and barrier function.