Yuan Shen

This study identifies local mechanical heterogeneity as the driver of epidermal cell delamination through force balance changes and actomyosin remodeling in keratinocytes.

This study shows curvature guides chiral organization and myogenic differentiation in myoblast tissues, with handedness determined by substrate curvature.

This study investigates the microscopic dynamics of cells in high-density epithelial tissues, revealing sub-diffusive creep and stress-driven fluidity despite their jammed state.

The paper introduces a method to analyze nematic order on tissue surfaces of arbitrary geometry, validated in vitro and in vivo, revealing physical insights through 3D reconstruction from 2D image stacks.

This paper identifies a new mode of large-scale collective motion in epithelial cells, showing they behave as polar elastic solids with scale-free correlations and Goldstone modes, distinct from fluid-like dynamics.