M. Y. Lee

Retinal microglia exacerbate uveitis by functioning as local antigen-presenting cells

This study shows retinal microglia are critical antigen-presenting cells in uveitis, essential for all phases of disease, while CD11c+ DCs are not required for all phases.

Nucleoporin93 (Nup93) Limits Yap Activity to Prevent Endothelial Cell Senescence

This study identifies Nup93 as a critical factor in maintaining endothelial cell health by preventing Yap nuclear accumulation and inflammation associated with aging.

Overexpression of Alpha-1 Antitrypsin Increases the Proliferation of Mesenchymal Stem Cells by Upregulation of Cyclin D1 and is Independent of the Wnt Signaling Pathway

A single cell spatial temporal atlas of skeletal muscle reveals cellular neighborhoods that orchestrate regeneration and become disrupted in aging

The paper constructs a single cell spatial temporal atlas of skeletal muscle to reveal cellular neighborhoods involved in regeneration and their disruption in aging.

Endothelial Nitric Oxide Synthase (eNOS) S1176 phosphorylation status governs atherosclerotic lesion formation

This study shows that phosphorylation of eNOS at S1176 by Akt determines atherosclerotic lesion formation, with phospho-mimic mutants reducing plaque while unphosphorylatable mutants increase it.

Versatile, do-it-yourself, low-cost spinning disk confocal microscope

This paper describes a low-cost DIY spinning disk confocal microscope module that enhances a standard epifluorescence microscope for 3D biological imaging.

Engineering sorghum for higher 4-hydroxybenzoic acid content

This paper engineers sorghum to overproduce 4-hydroxybenzoic acid by expressing modified bacterial enzymes, resulting in 1.56-1.72% dry weight accumulation without affecting biomass or agronomic traits.

PLK1 inhibition selectively kills ARID1A deficient cells through uncoupling of oxygen consumption from ATP production

This study identifies ARID1A deficiency as a biomarker for PLK1 inhibitor sensitivity by revealing a mitochondrial metabolic vulnerability in these cells.

Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

This study shows baricitinib reduces lung inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques without affecting viral shedding or immune responses.

Agrobacterium-mediated transient transformation of sorghum leaves for accelerating functional genomics and genome editing studies.

This paper develops an Agrobacterium-mediated transient transformation method for sorghum leaves to efficiently test vector constructs and genome editing tools.

Single-cell analysis of early antiviral gene expression reveals a determinant of stochastic IFNB1 expression

The paper identifies early antiviral gene expression patterns and shows that RLRs drive stochastic IFNB1 expression independent of IFN.

3D Single-Molecule Super-Resolution Microscopy With A Tilted Light Sheet

This paper introduces TILT3D, a 3D single-molecule super-resolution microscopy technique that enables high-precision imaging in thick cells using tilted light sheets and specialized PSFs.