Author

C. A. O'Brien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:flow cytometry· 1 Assay:proteomics· 1

Frequent Co-Authors

S. J. Batista· 4 shared J. A. Thompson· 3 shared K. M. Still· 3 shared M. A. Kovacs· 2 shared M. N. Cowan· 2 shared T. H. Harris· 2 shared T. Harris· 2 shared D. Johanson· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersImmunology

S. J. Batista

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Microglial STAT1-sufficiency is required for resistance to toxoplasmic encephalitis

M. N. Cowan, M. A. Kovacs, I. Sethi, I. W. Babcock, K. Still, S. J. Batista, C. A. O'Brien, J. A. Thompson, L. A. Sibley, S. A. Labuzan, T. H. Harris

This study shows that microglial STAT1 is essential for controlling T. gondii infection and preventing toxoplasmic encephalitis by regulating microglial activation and anti-parasitic functions.

bioRxiv · Jun 6, 2022Immunology

Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling

K. M. Still, S. J. Batista, C. A. O'Brien, O. O. Oyesola, S. Frueh, L. Webb, I. Smirnov, M. A. Kovacs, M. N. Cowan, N. W. Hayes, J. A. Thompson, E. D. Tait Wojno, T. H. Harris

This study shows that astrocytes use IL-33-ST2 signaling to promote protective immune responses against brain Toxoplasma gondii infection by recruiting anti-parasitic immune cells.

bioRxiv · May 7, 2020 · PreprintImmunology

Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection

S. J. Batista, K. M. Still, D. Johanson, J. A. Thompson, C. A. O'Brien, J. R. Lukens, T. Harris

bioRxiv · Jan 22, 2020Immunology

IL-10 and ICOS differentially regulate T cell responses in the brain during chronic Toxoplasma gondii infection

C. A. O'Brien, S. J. Batista, K. M. Still, T. Harris

This study investigates how IL-10 and ICOS differentially regulate T cell responses in the brain during chronic Toxoplasma gondii infection, showing distinct effects on inflammation and T cell dynamics.

bioRxiv · Sep 15, 2018Immunology