Author

T. H. Harris

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:flow cytometry· 2 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

M. A. Kovacs· 4 shared M. N. Cowan· 4 shared I. Sethi· 3 shared I. W. Babcock· 3 shared L. A. Sibley· 3 shared S. A. Labuzan· 3 shared S. J. Batista· 3 shared C. A. O'Brien· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

M. A. Kovacs

Mutual co-authors in cluster

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5 papers

Recent·Most cited

Caspase-1 in Cx3cr1-expressing cells drives an IL-18-dependent T cell response that promotes parasite control during acute T. gondii infection

I. W. Babcock, L. A. Sibley, S. A. Labuzan, M. N. Cowan, I. Sethi, S. Alemu, M. A. Kovacs, J. R. Lukens, T. H. Harris

This study shows that caspase-1 in Cx3cr1-expressing cells drives IL-18 release, enhancing CD4+ T cell IFN-γ production and parasite control during acute T. gondii infection.

bioRxiv · Jan 29, 2024 · PreprintImmunology

Impact of secondary TCR engagement on the heterogeneity of pathogen-specific CD8+ T cell response during acute and chronic toxoplasmosis

L. A. Shallberg, A. T. Phan, D. A. Christian, J. A. Perry, B. E. Haskins, D. P. Beiting, T. H. Harris, A. A. Koshy, C. A. Hunter

This paper investigates how secondary TCR engagement affects CD8+ T cell heterogeneity during acute and chronic toxoplasmosis, showing its role in effector responses but limited impact on memory populations.

PLOS Pathogens · Jun 21, 2022Peer-reviewedImmunology

Microglial STAT1-sufficiency is required for resistance to toxoplasmic encephalitis

M. N. Cowan, M. A. Kovacs, I. Sethi, I. W. Babcock, K. Still, S. J. Batista, C. A. O'Brien, J. A. Thompson, L. A. Sibley, S. A. Labuzan, T. H. Harris

This study shows that microglial STAT1 is essential for controlling T. gondii infection and preventing toxoplasmic encephalitis by regulating microglial activation and anti-parasitic functions.

bioRxiv · Jun 6, 2022Immunology

Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain

M. A. Kovacs, M. N. Cowan, I. W. Babcock, L. A. Sibley, K. Still, S. J. Batista, S. A. Labuzan, I. Sethi, T. H. Harris

bioRxiv · Jun 2, 2022Immunology

Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling

K. M. Still, S. J. Batista, C. A. O'Brien, O. O. Oyesola, S. Frueh, L. Webb, I. Smirnov, M. A. Kovacs, M. N. Cowan, N. W. Hayes, J. A. Thompson, E. D. Tait Wojno, T. H. Harris

This study shows that astrocytes use IL-33-ST2 signaling to promote protective immune responses against brain Toxoplasma gondii infection by recruiting anti-parasitic immune cells.

bioRxiv · May 7, 2020 · PreprintImmunology