C. A. Weber

The interplay between biomolecular assembly and phase separation

This paper develops a thermodynamic theory to explain the interplay between molecular assembly and phase separation, supported by in vitro experimental observations.

Liquid spherical shells are a non-equilibrium steady state

The paper studies chemically fueled phase separation, showing that spherical droplets can transition into stable liquid spherical shells sustained by continuous energy conversion.

Aggregation controlled by condensate rheology

This paper develops a theoretical model showing how condensate rheology controls linear aggregate formation, revealing switch-like changes in aggregate numbers with small rheological variations.

Stochastic dynamics of single molecules across phase boundaries

The paper derives a stochastic Langevin equation for molecular trajectories in phase-separated liquids and shows how non-equilibrium conditions lead to uphill drift in concentration gradients.

Quantitative Theory for the Diffusive Dynamics of Liquid Condensates

The paper develops a physics-based theory for quantifying diffusive dynamics in liquid condensates and validates it using fluorescence recovery after photobleaching experiments.

Local thermodynamics governs the formation and dissolution of protein condensates in living cells

The paper investigates how temperature changes affect P granule condensates in C. elegans, showing their reversible dissolution and recondensation, which can be modeled by thermodynamic equilibrium principles.

Optimal strategies for inhibition of protein aggregation

The paper uses aggregation kinetics and control theory to determine optimal drug protocols for inhibiting protein aggregation, finding different strategies are needed for primary and fibril-dependent secondary nucleation.