T. C. T. Michaels

This paper develops a thermodynamic theory to explain the interplay between molecular assembly and phase separation, supported by in vitro experimental observations.

The paper investigates A{beta}42 fibril self-replication using statistical mechanics and modeling, finding replication occurs on isolated small catalytic sites on the fibril surface.

This study investigates FUS liquid droplet maturation, revealing a solid beta-sheet surface layer that forms during aging, with RNA inhibiting this process.

The paper analyzes how phase-separated compartments affect chemical reaction rates, finding that optimal sticker affinity and compartment size can enhance reaction efficiency.

The paper derives an analytical solution for the Flory-Huggins model, showing its ability to extend phase space validity and reveal exponential scaling laws for protein phase separation.

This paper develops a theoretical model showing how condensate rheology controls linear aggregate formation, revealing switch-like changes in aggregate numbers with small rheological variations.

This study quantitatively models protein aggregation in C. elegans using a molecular framework, showing that nucleation rates and stochasticity drive aggregation in vivo, consistent with in vitro findings.