A. W. Fritsch

Actin polymerization counteracts prewetting of N-WASP on supported lipid bilayers

The paper shows that actin polymerization counteracts N-WASP prewetting on lipid bilayers, revealing a balance between condensate formation and dissolution in cortical condensates.

Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis models

The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.

Predicting disordered regions driving phase separationof proteins under variable salt concentration

The paper predicts disordered regions driving phase separation of proteins under variable salt concentration using a theoretical model validated against experimental data.

Local thermodynamics governs the formation and dissolution of protein condensates in living cells

The paper investigates how temperature changes affect P granule condensates in C. elegans, showing their reversible dissolution and recondensation, which can be modeled by thermodynamic equilibrium principles.

Material aging causes centrosome weakening and disassembly during mitotic exit

The paper investigates how centrosome material properties change during mitotic exit in C. elegans embryos, finding that PLK-1 and SPD-2 confer strength and ductility before anaphase, which is lost as centrosomes transition to a brittle state.