Author

C. Bull

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

P. D. Dunne· 2 shared A. Ashikov· 1 shared A. Aspin· 1 shared A. Bogdanove· 1 shared A. D. Campbell· 1 shared A. F. Munro· 1 shared A. Ryan· 1 shared A. Willems· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCancer Biology

P. D. Dunne

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Author profile →

5 papers

Recent·Most cited

Evaluation of Gene Set Enrichment Analysis (GSEA) tools highlights the value of single sample approaches over pairwise for robust biological discovery.

C. Bull, R. M. Byrne, N. C. Fisher, S. M. Corry, R. Amirkhah, J. Edwards, L. Hillson, M. Lawler, A. Ryan, F. Lamrock, P. D. Dunne, S. B. Malla

This study compares GSEA tools and finds single sample approaches better capture biological distinctions than pairwise methods in cancer recurrence analysis.

bioRxiv · Mar 15, 2024 · PreprintCancer Biology

A targetable PREX2/RAC1/PI3Kβ signalling axis confers resistance to clinically relevant therapeutic approaches in melanoma

C. A. Ford, D. Koludrovic, P. P. Centeno, M. Foth, E. Tsonou, N. Vlahov, N. Sphyris, K. Gilroy, C. Bull, C. Nixon, B. Serrels, A. F. Munro, J. C. Dawson, N. O. Carragher, V. Pavet, , A. D. Campbell

This study identifies a druggable PREX2/RAC1/PI3Kβ signalling axis in BRAF-mutant melanoma that confers resistance to therapies and can be targeted to improve treatment outcomes.

bioRxiv · Feb 26, 2024Cancer Biology

Dynamic analysis of sugar metabolism reveals the mechanisms of action of synthetic sugar analogs

M. v. Scherpenzeel, F. Conte, C. Bull, A. Ashikov, E. Hermans, A. Willems, W. v. Tol, E. Kragt, E. Moret, T. Heise, J. Langereis, E. Rossing, M. Zimmermann, E. M. Rubio-Gozalbo, M. d. Jonge, , D. Lefeber

This study dynamically analyzes sugar metabolism to uncover how synthetic sugar analogs are metabolized and their effects on cellular pathways.

bioRxiv · Sep 15, 2020 · PreprintBiochemistry

Exposure to hypomethylating agent 5-aza-2-deoxycytidine (decitabine) causes rapid, severe DNA damage, telomere elongation and mitotic dysfunction in human WIL2-NS cells

C. Bull, G. Mayrhofer, M. Fenech

This study shows that 5-aza-2-deoxycytidine causes DNA damage, telomere elongation, and mitotic dysfunction in human WIL2-NS cells at clinically relevant doses.

bioRxiv · Nov 7, 2019Cancer Biology

Transfer of Xanthomonas campestris pv. arecae, and Xanthomonas campestris pv. musacearum to Xanthomonas vasicola (Vauterin) as Xanthomonas vasicola pv. arecae comb. nov., and Xanthomonas vasicola pv. musacearum comb. nov. and description of Xanthomonas vasicola pv. vasculorum pv. nov.

D. J. Studholme, E. Wicker, A. Aspin, A. Bogdanove, K. Broders, Z. Dubrow, M. Grant, J. B. Jones, G. Karamura, J. Lang, J. Leach, S. M. Abrare, G. Mahuku, G. V. Nakato, T. Coutinho, , C. Bull

The paper transfers two Xanthomonas species to Xanthomonas vasicola and describes a new pathovar.

bioRxiv · Mar 25, 2019Microbiology