N. O. Carragher

A targetable PREX2/RAC1/PI3Kβ signalling axis confers resistance to clinically relevant therapeutic approaches in melanoma

This study identifies a druggable PREX2/RAC1/PI3Kβ signalling axis in BRAF-mutant melanoma that confers resistance to therapies and can be targeted to improve treatment outcomes.

Single-cell morphological tracking of liver cell states to identify small-molecule modulators of liver differentiation

A cautionary note on the use of N-acetylcysteine as a reactive oxygen species antagonist to assess copper mediated cell death.

This paper shows that N-acetylcysteine reduces copper uptake rather than quenching reactive oxygen species, challenging the current understanding of copper-induced cell death mechanisms.

A novel ILK/STAT3 pathway controls plasticity in a neural stem cell model of glioblastoma.

This study identifies a novel ILK-STAT3 pathway that regulates phenotypic plasticity and mesenchymal state in mouse glioblastoma stem cells.

High-content profiling reveals a unified model of copper ionophore dependent cell death in oesophageal adenocarcinoma

This study identifies a unified mechanism of copper ionophore-induced cell death in oesophageal adenocarcinoma using high-content profiling and omic analyses.

Multicenter reverse-phase protein array data integration

This paper integrates multicenter reverse-phase protein array data from breast cancer cell responses to two drugs, quantifying 86,832 spots across three platforms to create a public resource for comparing RPPA workflows.

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors.

This study profiles the effects of the SRC inhibitor AZD0424 in combination with MEK inhibitors, showing reduced compensatory activation and enhanced anti-tumor effects in colorectal cancer models.

Optimized chemogenomic library design strategies for precision oncology

The paper presents strategies for designing optimized chemogenomic libraries for precision oncology, focusing on cancer-related targets and biological pathways.

High Content Phenotypic Profiling in Oesophageal Adenocarcinoma Identifies Selectively Active Pharmacological Classes of Drugs for Repurposing and Chemical Starting Points for Novel Drug Discovery

This study uses high-content phenotypic profiling to identify drug classes and novel compounds with selective activity against oesophageal adenocarcinoma cell lines.

Chemical-Genetic Interrogation of Nuclear Size Control Reveals Cancer-Specific Effects on Cell Migration and Invasion

The paper identifies compounds that reverse nuclear size changes in cancer cell lines and finds they inhibit cell migration and invasion.

Integrative analysis of multi-platform reverse-phase protein array data for the pharmacodynamic assessment of response to targeted therapies

The paper assesses variability between RPPA platforms and identifies consistent protein expression and phosphorylation signatures across different platforms and workflows.

ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling

This study shows that ISGylation promotes breast tumour progression by enhancing EGFR recycling and Akt signalling, acting as a driver rather than just a marker of cancer.

A Synergistic Anti-Cancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High Content Phenotypic Screen

The paper identifies a synergistic combination of FAK and HDAC inhibitors using a chemical-genetic high-content screen, showing efficacy in cancer cell lines and in vivo.