GHB confers neuroprotection by stabilizing the CaMKIIα hub domain
U. Leurs, A. B. Klein, E. D. McSpadden, N. Griem-Krey, S. M. Solbak, J. Houlton, I. S. Villumsen, S. B. Vogensen, L. Hamborg, S. J. Gauger, L. B. Palmelund, A. S. G. Larsen, M. A. Shehata, C. D. Kelstrup, J. V. Olsen, , P. Wellendorph
This study shows that GHB stabilizes the CaMKII hub domain, providing neuroprotection in cellular and mouse models.
bioRxiv · Sep 28, 2020 · PreprintBiochemistry