Author

A. B. Klein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. M. Fritzen· 2 shared A. N. Clarkson· 2 shared C. Clemmensen· 2 shared J. Lund· 2 shared K. Karstoft· 2 shared M. Kleinert· 2 shared N. Griem-Krey· 2 shared P. Wellendorph· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersPhysiology

A. M. Fritzen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The GHB analogue HOCPCA improves sensorimotor function after MCAO via CaMKIIα

N. Griem-Krey, A. B. Klein, B. H. Clausen, M. R. Namini, P. V. Nielsen, H. Chin-Cheng, C. Orset, D. Vivien, A. N. Clarkson, K. L. Lambertsen, P. Wellendorph

The paper shows HOCPCA, a GHB ligand, improves sensorimotor function after stroke in mice by modulating CaMKII signaling and reducing aberrant activity.

bioRxiv · Mar 10, 2022 · PreprintPharmacology & Toxicology

The GDF15-GFRAL pathway is dispensable for the effects of metformin on energy balance

A. B. Klein, T. S. Nicolaisen, K. Johann, A. M. Fritzen, C. V. Mathiesen, C. Gil, N. S. Pilmark, K. Karstoft, M. B. Blond, J. S. Quist, R. J. Seeley, K. Faerch, J. Lund, M. Kleinert, C. Clemmensen

This study shows metformin increases GDF15 but does not rely on the GDF15-GFRAL pathway for its weight-lowering effects in mice.

bioRxiv · Feb 16, 2022Physiology

Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise

A. B. Klein, T. S. Nicolaisen, N. Ortenblad, K. D. Gejl, R. Jensen, A. M. Fritzen, E. L. Larsen, K. Karstoft, H. E. Poulsen, T. Morville, R. E. Sahl, J. W. Helge, J. Lund, S. Falk, M. Lyngbaek, , C. Clemmensen

The paper shows that exercise increases circulating GDF15 levels, but this physiological increase does not suppress appetite or exercise motivation like pharmacological GDF15.

bioRxiv · Oct 23, 2020Physiology

GHB confers neuroprotection by stabilizing the CaMKIIα hub domain

U. Leurs, A. B. Klein, E. D. McSpadden, N. Griem-Krey, S. M. Solbak, J. Houlton, I. S. Villumsen, S. B. Vogensen, L. Hamborg, S. J. Gauger, L. B. Palmelund, A. S. G. Larsen, M. A. Shehata, C. D. Kelstrup, J. V. Olsen, , P. Wellendorph

This study shows that GHB stabilizes the CaMKII hub domain, providing neuroprotection in cellular and mouse models.

bioRxiv · Sep 28, 2020 · PreprintBiochemistry